Causal associations between osteoporosis and HBV infection across Asian and European populations: evidence from Mendelian randomization and colocalization analysis.

ABSTRACT:

Introduction

Clinical studies have demonstrated a potential association between chronic hepatitis caused by hepatitis B virus (HBV) infection and osteoporosis. However, the causal relationship between HBV infection and osteoporosis remains to be determined.

Methods

We investigated whether HBV infection is causally associated with osteoporosis using Mendelian randomization (MR) in East Asian and European populations, respectively. The data we utilized were obtained from the genome-wide association studies (GWAS) database. Various MR methods, including inverse variance weighted (IVW), MR Egger, weighted median, simple median and simple mode were employed to estimate the association between HBV infection and osteoporosis. Heterogeneity analysis and sensitivity tests were perfor

SUBMITTER: Li Z 

PROVIDER: S-EPMC11794126 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature