Associations of combined exposure to selected metal mixtures with thyroid hormones in children: a cross-sectional study in China.

ABSTRACT:

Background

Exposure to several metal elements has been found to be associated with thyroid hormone homeostasis. However, evidence for combined exposure is inconclusive, especially for children.

Objective

To examine the individual and joint effects of blood metal elements on thyroid hormones in children.

Methods

A total of 12,470 children aged 0-14 were collected from January 2018 to December 2021 in Hunan Children's Hospital. The concentrations of lead (Pb), iron (Fe), calcium (Ca), copper (Cu), zinc (Zn) and magnesium (Mg) in blood were detected via atomic absorption spectrometry (AAS). The levels of thyroid stimulating hormone (TSH), triiodothyronine (TT3, FT3) and total and free thyroxine (TT4, FT4) were measured by electrochemiluminescence immunoassay (ECLIA). Gen

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11794202 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature