In silico design of an epitope-based vaccine ensemble for fasliolopsiasis.

ABSTRACT:

Introduction

Fasciolopsiasis, a food-borne intestinal disease is most common in Asia and the Indian subcontinent. Pigs are the reservoir host, and fasciolopsiasis is most widespread in locations where pigs are reared and aquatic plants are widely consumed. Human infection has been most commonly documented in China, Bangladesh, Southeast Asia, and parts of India. It predominates in school-age children, and significant worm burdens are not uncommon. The causal organism is Fasciolopsis buski, a giant intestinal fluke that infects humans and causes diarrhoea, fever, ascites, and intestinal blockage. The increasing prevalence of medication resistance and the necessity for an effective vaccination make controlling these diseases challenging.

Methods

Over the last decade, we

SUBMITTER: Konhar R 

PROVIDER: S-EPMC11794225 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature