Activation of the periaqueductal gray controls respiratory output through a distributed brain network.

ABSTRACT:

Introduction

The periaqueductal gray (PAG) has been previously established to play a key role in producing the vital changes in respiration occurring in response to threat. However, it is not fully understood how PAG activation alters the ongoing respiratory output, nor it is understood which pathways mediate these effects, as several regions have been previously identified to influence respiratory activity.

Methods

We used optogenetic tools in conjunction with EMG recordings of inspiratory and expiratory musculature to determine how PAG activation on short (250 ms) and longer (10-15 s) timescales alters respiratory muscle activity. Through cFOS mapping, we also identified key downstream brain regions which were likely modulated by PAG activation including the preBötzinger C

SUBMITTER: Prostebby M 

PROVIDER: S-EPMC11794281 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature