Efferocytosis-related gene IL33 predicts prognosis and immune response and mediates proliferation and migration <i>in vitro</i> and <i>in vivo</i> of breast cancer.

ABSTRACT:

Background

Breast cancer (BRCA) has a high incidence among women, with poor prognosis and high mortality, which is increasing year by year. Efferocytosis is a process of phagocytosis of abnormal cells and is of great value in tumor research. Our study seeks to create a predictive model for BRCA using efferocytosis-related genes (ERGs) to explore the significance of efferocytosis in this disease.

Methods

In this research, Differential analysis, and univariate Cox regression were employed to identify genes linked to prognosis in BRCA patients. Then the BRCA patients were categorized into distinct groups using consensus clustering based on prognosis genes. Survival analysis, PCA, and t-SNE were performed to verify these groups. The enrichment of metabolic pathways within the de

SUBMITTER: He X 

PROVIDER: S-EPMC11794308 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature