Is tumour location a dominant risk factor of recurrence in early rectal cancer?

ABSTRACT:

Background

Impact of rectal tumour location on risk of lymph node metastases (LNM) and recurrence in early RC is poorly studied and elusive. Tumour location as a prognostic factor may contribute to optimise management of early RC in the future. The aim of this study was to investigate rectal tumour location as an independent predictor of oncologic outcome in early rectal cancer (RC).

Methods

Retrospective multicentre national cohort study on prospectively collected data on all patients with T1-T2 RC, undergoing surgical resection between 2009 and 2021. Tumour location was categorised as distal (0-5 cm), mid (5-10 cm), and proximal (10-16 cm), measured from the anal verge.

Results

Incidence of LNM in the 2424 included T1-T2 RC patients was 18.2%, 17.3% and 21.6% for di

SUBMITTER: Rosen R 

PROVIDER: S-EPMC11794355 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature