Immune regulatory genes impact the hot/cold tumor microenvironment, affecting cancer treatment and patient outcomes.

ABSTRACT:

Background and aims

Immunologically hot tumors, characterized by an inflamed tumor microenvironment (TME), contrast significantly with immunologically cold tumors. The identification of these tumor immune subtypes holds clinical significance, as hot tumors may exhibit improved prognoses and heightened responsiveness to checkpoint blockade therapy. Nevertheless, as yet there is no consensus regarding the clinically relevant definition of hot/cold tumors, and the influence of immune genes on the formation of hot/cold tumors remains poorly understood.

Methods

Data for 33 different types of cancer were obtained from The Cancer Genome Atlas database, and their immune composition was assessed using the CIBERSORT algorithm. Tumors were categorized as either hot or cold based on the

SUBMITTER: Sang M 

PROVIDER: S-EPMC11794490 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature