Effect of β-blocker on clinical outcomes in patients with traumatic brain injury: a retrospective propensity-matched study.

ABSTRACT:

Background

Traumatic brain injury (TBI) represents a significant public health challenge due to its complex management. β-blockers may offer neuroprotective benefits, but their impact on TBI outcomes remains unclear. This study aims to evaluate the effect of β-blocker use on clinical outcomes in TBI patients.

Methods

This retrospective cohort study included adult TBI patients, categorized into β-blocker and non-β-blocker groups. Propensity score matching (PSM) was utilized to balance baseline characteristics. Mortality was assessed through the application of multivariable Cox regression models and Kaplan-Meier survival curves. Subgroup analyses examined the consistency of the results.

Results

A total of 1,516 patients were included in the study, with 750 receiving β-b

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11794503 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature