<i>Bifidobacterium animalis</i> BD400 protects from collagen-induced arthritis through histidine metabolism.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Numerous clinical studies have indicated a correlation between alterations in gut microbiota and the onset and progression of RA. This research aims to restore intestinal microbiota to a healthy state through the oral administration of Bifidobacterium in the early stages with the goal of delaying the onset and progression of RA.

Methods

Collagen-induced arthritis (CIA) rat model was constructed to assess the development of RA using arthritis clinical scores, paw thickness, pathological analysis of knee joint. The immune response was evaluated by determinating specific antibodies and cytokines in serum and synovial fluid. The expression of intestinal barrier protein was analyzed b

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11794514 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature