<i>Periplanta americana</i> extract regulates the Th17/Treg cell balance via Notch1 in ulcerative colitis.

ABSTRACT:

Background

Periplanta americana extract (PAE), a traditional Chinese medicine (TCM) from Shen Nong Ben Cao Jing, has been used to treat ulcerative colitis (UC), various types of wounds and ulcers, infantile malnutrition, palpitation, asthma, and so on. However, the exact mechanisms of PAE in UC have still not been fully revealed. The study aims to explore the therapeutic effects and mechanisms of PAE in UC.

Methods

The efficacy of PAE was evaluated using a DSS-induced UC mice model and the colon inflammation and mucosal barrier were comprehensively assessed. Furthermore, Network pharmacological analysis was utilized to identify potential targets and signaling pathways of PAE in the UC treatment. The proportion and the markers of Th17 and Treg cells in the splee

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC11794537 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature