N-Cadherin based adhesion and Rac1 activity regulate tension polarization in the actin cortex.

ABSTRACT: Tension-adhesion interplay is a crucial mechanism in multicellular organisms that determines the tension differential among internal and external interfaces, which in turn, mediates tissue surface tension and cell sorting, morphogenesis and remodeling, and cancer progression. Cadherins are widely believed to be involved, yet key aspects of the process are neither well characterized nor quantified. This study demonstrates the critical role of N-cadherin in driving tension polarization throughout the actin cortical network. N-cadherin regulates both tension increase at the cell-medium (external) interface and decrease at the cell-cell (internal) interface, and their quantitative magnitudes, both absolute and relative, strongly depend on the surface density of N-cadherin. Furthermore, the str

SUBMITTER: Moazzeni S 

PROVIDER: S-EPMC11794589 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature