Photoredox/Cr-catalyzed enantioselective radical-polar crossover transformation via C-H functionalization.

ABSTRACT: Asymmetric multicomponent reactions that aim to control multiple chiral centers with high selectivity in a single step remain an on-gonging challenge. The realm of enantioselective radical-polar crossover transformation achieved through C-H Functionalization has yet to be fully explored. Herein, we present a successful description of a photoredox/Cr-catalyzed enantioselective three-component (hetero)arylalkylation of 1,3-dienes through C-H functionalization. A diverse array of chiral homoallylic alcohols could be obtained in good to excellent yields, accompanied by outstanding enantioselectivity. The asymmetric radical-polar crossover transformation could build two chiral centers simultaneously and demonstrates broad substrate tolerance, accommodating various drug-derived aldehydes, (heter

SUBMITTER: Tang SY 

PROVIDER: S-EPMC11794612 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature