Integrative bioinformatic approach reveals novel melatonin-related biomarkers for Alzheimer's disease.

ABSTRACT:

Background

Melatonin (MLT) can improve mitophagy, thereby ameliorating cognitive deficits in Alzheimer's disease (AD) patients. Hence, our research focused on the potential value of MLT-related genes (MRGs) in AD through bioinformatic analysis.

Methods

First, the key cells in the single-cell dataset GSE138852 were screened out based on the proportion of annotated cells and Fisher's test between the AD and control groups. The differentially expressed genes (DEGs) in the key cell and GSE5281 datasets were identified, and the MRGs in GSE5281 were selected via weighted gene coexpression network analysis. After intersecting two sets of DEGs and MRGs, we performed Mendelian randomization analysis to identify the MRGs causally related to AD. Biomarkers were further ascertained thro

SUBMITTER: Zhang HX 

PROVIDER: S-EPMC11794634 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature