The prevalence, clinical features, and long-term outcome of patients with primary Sjogren's syndrome with renal involvement.

ABSTRACT: This multicenter, retrospective longitudinal study identified primary Sjögren's syndrome (pSS) patients with clinically significant renal involvement, and analyzed factors associated with predisposition. To investigate clinical features and long-term prognosis of renal involvement, we compared the clinical outcomes for the entire cohort based on the presence or absence of renal involvement. Among 1306 pSS patients (mean age, 51 ± 12 years; 98% female), 36 (2.8%) had renal involvement; 17 patients had tubular involvement, 15 had glomerular involvement, one had both, and 3 were unclassified. The presence of anti-La antibodies was associated with renal involvement. Over the median 5-year follow-up period, the renal function did not change significantly; however, 44% of patients with renal inv

SUBMITTER: Jeon H 

PROVIDER: S-EPMC11794661 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature