The prognostic significance of tertiary lymphoid structures in oral squamous cell carcinomas: a systematic review.

ABSTRACT:

Introduction

Upper aerodigestive tract cancers are prevalent, with a global incidence surpassing 500,000 new cases in 2018. Among these, oral squamous cell carcinomas (OSCC) constitute the majority. OSCC has a low 5-year survival rate due to late-stage diagnosis. Risk factors include alcohol and tobacco use. However, non-smokers and non-drinkers are also affected, especially young patients with tongue cancer. The impact of tumor microenvironment (TME) and tumor-infiltrating lymphocytes (TILs) on OSCC prognosis remains debated. Remarkably, Tertiary Lymphoid Structures (TLS) identified in solid tumors have shown associations with favorable outcomes, yet their prognostic significance in OSCC remains understudied.

Objective

Thus, this systematic review aims to explore the value

SUBMITTER: Ribeiro V 

PROVIDER: S-EPMC11794802 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature