Electrophysiological properties of melanin-concentrating hormone neuron subpopulations defined by anatomical localization and CART expression.

ABSTRACT:

Introduction

Melanin-concentrating hormone (MCH) neurons are essential regulators of energy and glucose homeostasis, sleep-wake behaviors, motivation, learning and memory. These neurons are anatomically distributed across the medial (MH) and lateral hypothalamus (LH), and the adjacent zona incerta (ZI), which may represent functional subgroups with distinct connectivity with different brain regions. Furthermore, MCH neurons can be classified according to co-expression of neuropeptides, such as cocaine and amphetamine- regulated transcript (CART).

Methods

To identify functional similarities and differences of MCH subpopulations, we characterized their intrinsic electrophysiological properties using whole cell current clamp recording on acute brain slices from male and female

SUBMITTER: Adekunle RD 

PROVIDER: S-EPMC11794810 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature