Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity.

ABSTRACT: Neutrophils are rapidly recruited to sites of infection, injury, or to immune complexes. Upon arrival, they initiate degranulation, release reactive oxygen species (ROS), and/or nuclear extracellular traps (NETs) to eliminate invading microorganisms, clear debris, or remove abnormal immunoglobulins. While these processes ideally trigger healing and a return to balance, overshooting neutrophil function can lead to life-threatening infections such as sepsis or persistent inflammation observed in various autoimmune diseases. However, recent evidence highlights a phenotypic and functional heterogeneity of neutrophils that extends well beyond their traditional - potentially harmful- role as first responders. For example, neutrophils regulate ongoing inflammation by modulating macrophage functio

SUBMITTER: Raudszus L 

PROVIDER: S-EPMC11794831 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature