Real world study on combining local interventions with systemic therapy in unresectable hepatocellular carcinoma.

ABSTRACT:  Combining local interventions with tyrosine kinase inhibitors (TKIs) plus anti-PD-1 antibodies in a triple therapy has demonstrated remarkable anti-tumor efficacy and facilitated conversion resection in patients with initially unresectable hepatocellular carcinoma (HCC). However, the long-term survival outcomes remain largely unexplored. This study focused on a cohort of consecutive patients who underwent triple therapy for initially unresectable HCC at the authors' hospital between January 2020 and December 2022. Specifically, patients who exhibited a positive response to triple therapy and fulfilled the criteria for hepatectomy were selected for liver resection. Additionally, investigation assessed association between clinical factors and successful achievement of conversion resection,

SUBMITTER: Xue Z 

PROVIDER: S-EPMC11794854 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature