Type 2-high airway inflammation in childhood asthma distinguishes a more severe phenotype.

ABSTRACT:

Background

It remains unclear whether phenotyping of type 2-high (T2-high) asthma can distinguish clinical characteristics and lung function trajectories in childhood.

Objective

To explore differences between T2-high and T2-low asthma from birth to age 18 years.

Methods

We included 47 children with asthma and 165 as a control group from the Copenhagen Prospective Studies on Asthma in Childhood₂₀₀₀ mother-child cohort. T2-high and T2-low asthma was defined at age 7 by sensitization to aeroallergens, elevated eosinophilic blood count, and/or elevated fractional nitric oxide. Lung function measurements included whole-body plethysmography, spirometry, exercise test, cold air provocation, and methacholine challenge. Differences in lung function trajectories and

SUBMITTER: Skov FR 

PROVIDER: S-EPMC11794961 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature