Serum proteomic correlates of mental health symptoms in a representative UK population sample.

ABSTRACT: Poor mental health constitutes a public health crisis due to its high prevalence, unmet need and its mechanistic heterogeneity. A comprehensive understanding of the biological correlates of poor mental health in the population could enhance epidemiological research and eventually help guide treatment strategies. The human bloodstream contains many proteins, several of which have been linked to diagnosed mental health conditions but not to population mental health symptoms, however recent technological advances have made this possible. Here we perform exploratory factor analyses of 184 proteins from two panels (cardiometabolic and neurology-related) measured using proximity extension assays from Understanding Society (the UK Household Longitudinal Study; UKHLS). Data reduction results in 28

SUBMITTER: Dearman A 

PROVIDER: S-EPMC11795072 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature