Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone.

ABSTRACT: Air pollution exposure, especially particulate matter (PM) and ozone (O₃), poses significant health risks, but the systemic metabolic consequences of combined exposures to PM and O₃, remain poorly understood. This study investigated systemic metabolic changes in male spontaneously hypertensive (SH) rats following inhalation exposure to concentrated ambient particles (CAPs) (PM2.5, 150 μg/m³), ozone (O₃) (0.2 ppm), and their combination. Rats were exposed for 4 h, and serum samples were collected 1-hour post-exposure. Using targeted metabolomics, we identified significant alterations in metabolites involved in lipid metabolism (phosphatidylcholines), energy metabolism (acylcarnitine C3), and oxidative stress (glutamine). Notably, the combination e

SUBMITTER: Ge Y 

PROVIDER: S-EPMC11795073 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature