New insights into the N-glycomes of <i>Dictyostelium</i> species.

ABSTRACT: Dictyostelia are cellular slime molds, a group of Amoebozoa, that form multicellular fruiting bodies out of aggregating cells able of differentiating into resistant spore forms. In previous studies on Dictyostelium discoideum, it was demonstrated that their N-glycans, as in most eukaryotes, derive from the Glc₃Man₉GlcNAc₂-PP-Dol precursor; however, unique glyco-epitopes, including intersecting GlcNAc, core α1,3-fucosylation, sulphation and methylphosphorylation, were detected. In the present study, we have examined the N-glycans of two other Dictyostelium species, D. purpureum, whose genome is also sequenced, and D. giganteum. The detailed glycomic analysis of their fruiting bodies was based on isomeric separation of the glycan s

SUBMITTER: Hykollari A 

PROVIDER: S-EPMC11795075 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature