Report of joint hypermobility in malignant hyperthermia susceptible patients: Observational study with a case-control descriptive design.

ABSTRACT:

Background

Hypermobility is the capacity to perform joint movements in amplitudes greater than normal. Hypermobility is present in nearly 100 % of congenital myopathy central core disease (CCD) patients but is sporadically described in the allelic disease malignant hyperthermia (MH). Our objective was to investigate the frequency/characteristics of hypermobility in MH susceptible patients as compared to a control group, aiming the identification of correlations between hypermobility and demographic/clinical findings in MH patients.

Methods

We recruited 26 MH patients (MH history, positive in vitro contracture test (IVCT), no muscle weakness, no cores in muscle biopsy) and 23 controls (no MH/myopathy history). Patients/medical records were evaluated for obtaining demog

SUBMITTER: Santos RC 

PROVIDER: S-EPMC11795088 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature