CKD patients comorbid with hypertension are associated with imbalanced gut microbiome.

ABSTRACT: Intestinal flora has been linked to chronic kidney disease (CKD) and hypertension, respectively. This study aimed to investigate the microbial community among 54 individuals without CKD, 46 hypertensive CKD patients (CKD_HTN), and 48 non-hypertensive CKD patients. Variations in microbial diversity were detected in CKD. The Prevotella-dominated type progressively increased from CKD to CKD_HTN. Based on the variation patterns, we identified six distinct clusters. Klebsiella, Turicibacter, and Enterobacter were enriched in CKD, whereas Escherichia and Mogibacterium were elevated, and Blautia and Clostridium were reduced in CKD_HTN. Enhanced phenylalanine metabolism and siderophore group nonribosomal peptides biosynthesis from non-CKD to

SUBMITTER: Wang P 

PROVIDER: S-EPMC11795142 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature