Sex differences in murine MASH induced by a fructose-palmitate-cholesterol-enriched diet.

ABSTRACT:

Background & aims

Metabolic syndrome-associated steatotic liver disease (MASLD) and metabolic syndrome-associated steatohepatitis (MASH) have global prevalence rates exceeding 25% and 3-6%, respectively. The introduction of high-fructose corn syrup to the diet in the 1970s has been linked to metabolic and hepatic disturbances. Despite these associations, the potential for sex-dependent responses resulting from fructose-containing diets on MASLD/MASH has not been addressed.

Methods

Female and male C57BL/6J mice were fed a fructose-palmitate-cholesterol (FPC)-NASH diet vs. standard chow for 16 weeks (n = 40 mice). At sacrifice, plasma and liver were retrieved, the latter for single-nucleus RNA sequencing. Publicly available data sets of human male and female MASH liver

SUBMITTER: Arivazhagan L 

PROVIDER: S-EPMC11795143 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature