Block copolymer-assembled nanopore arrays enable ultrasensitive label-free DNA detection.

ABSTRACT: DNA detection via nanoporous-based electrochemical biosensors is a promising method for rapid pathogen identification and disease diagnosis. These sensors detect electrical current variations caused by DNA hybridization in a nanoporous layer on an electrode. Current fabrication techniques for the typically micrometers-thick nanoporous layer often suffer from insufficient control over nanopore dimensions and involve complex fabrication steps, including handling and stacking of a brittle porous membrane. Here, we introduce a bottom-up fabrication process based on the self-assembly of high molecular weight block copolymers with sol-gel precursors to create an inorganic nanoporous thin film directly on electrode surfaces. This approach eliminates the need for elaborate manipulation of t

SUBMITTER: Fornerod MJJ 

PROVIDER: S-EPMC11795167 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature