6-Nitrodopamine potentiates catecholamine-induced contractions of human isolated vas deferens.

ABSTRACT: 6-Nitrodopamine (6-ND) is the main catecholamine released from human isolated vas deferens and the adrenergic nervous system is known to play a major role in the contractions of the epididymal portion of the vas deferens. Here it was investigated the interactions of 6-ND on the contractions of the human isolated vas deferens induced by either classical catecholamines or electric-field stimulation (EFS). The vas deferens obtained from 106 patients who underwent vasectomy surgery were mounted in a 10-mL glass chamber filled with warmed (37°C) and oxygenated Krebs-Henseleit's solution. The strips were pretreated (30 min) with 6-ND (0.1-100 nM) and exposed to increasing concentrations of noradrenaline (0.01-300 M), dopamine (0.00001-10 mM), or adrenaline (0.01-300 M). The strips were also subm

SUBMITTER: Lima AT 

PROVIDER: S-EPMC11795274 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature