Changes in Incident Schizophrenia Diagnoses Associated With Cannabis Use Disorder After Cannabis Legalization.

ABSTRACT:

Importance

Despite public health concerns that cannabis legalization may increase the number of cases of schizophrenia caused by cannabis, there is limited evidence on this topic.

Objective

To examine changes in the population-attributable risk fraction (PARF) for cannabis use disorder (CUD) associated with schizophrenia after liberalization of medical cannabis and legalization of nonmedical cannabis in Canada.

Design, setting, and participants

This population-based cohort study was conducted in Ontario, Canada, from January 1, 2006, to December 31, 2022, among 13 588 681 people aged 14 to 65 years without a history of schizophrenia.

Exposures

Diagnosis of CUD in the emergency department or hospital setting (International Statistical Classification of Diseases

SUBMITTER: Myran DT 

PROVIDER: S-EPMC11795325 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature