Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study.

ABSTRACT:

Background

Human milk (HM) is considered a potential protective factor against bronchopulmonary dysplasia (BPD), but the specific volume needed for its protective effect in mixed feeding is unclear. This study aimed to investigate the impact of different HM volumes on BPD risk.

Methods

A retrospective cohort study examined the association between HM volume and BPD risk in very low birthweight (VLBW) infants. Dose-dependent analysis with spline smoothing curve and univariate, multivariate analyses and sensitivity analyses were conducted.

Result

The study included 339 VLBW infants. BPD incidence was 4.7% (6 infants) in the high HM group (HM volume≥1190 mL), 27.0% (48 infants) in the low HM group (HM volume<1190 mL) and 9.1% (3 infants) in the exclusive formula group, an

SUBMITTER: Yang J 

PROVIDER: S-EPMC11795393 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature