Evaluation of oral cholera vaccine (Euvichol-Plus) effectiveness against <i>Vibrio cholerae</i> in Bangladesh: an interim analysis.

ABSTRACT:

Introduction

Millions of Euvichol-Plus doses have been deployed from the global oral cholera vaccine stockpile in over 20 cholera-affected countries. However, information on Euvichol-Plus's effectiveness is limited. Using this vaccine in a cholera epidemic in Dhaka, Bangladesh, provided the opportunity to evaluate the vaccine effectiveness (VE) using a test-negative design.

Methods

A two-dose regimen of Euvichol-Plus was administered to individuals aged >1 year in a population of ca. 900 000 in two campaign rounds between June and August 2022, with prospective registration of all persons who received at least one dose. We conducted systematic surveillance in two key facilities, enrolling patients with acute watery diarrhoea who were eligible for vaccination from the campaign

SUBMITTER: Khanam F 

PROVIDER: S-EPMC11795403 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature