Health Economic Evaluations of Circulating Tumor DNA Testing for Cancer Screening: Systematic Review.

ABSTRACT:

Background

Cancer detection remains a significant global healthcare challenge, and circulating tumor DNA (ctDNA) is a biomarker for noninvasive cancer screening.

Objective

This systematic review aimed to describe health economic evaluations of ctDNA for cancer screening.

Methods

A comprehensive literature search was performed (following PRISMA guidelines) across MEDLINE, Embase, APA PsycINFO, Cochrane Library, Web of Science, and the Center for Review and Dissemination. The review included full-scale health economic analyses such as cost-effectiveness, cost-utility, cost-benefit, and cost-consequence analyses. The quality of the included reports was assessed using CHEERS 2022 standards, and each report was categorized as excellent, very good, good, or insufficient.

SUBMITTER: Rui M 

PROVIDER: S-EPMC11795416 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature