Anticholinergic drugs and dementia risk: Using stem cell-based studies to complement pharmacoepidemiology.

ABSTRACT:

Background

Anticholinergic (AC) use remains common in older adults despite evidence of safety risks, including increased risk in dementia. Pharmacoepidemiology studies from various populations report associations between specific anticholinergic classes - antidepressants and bladder antimuscarinics - and increased dementia incidence. However, it is difficult to determine whether these associations are directly caused by the neurotoxic effects of anticholinergic drugs or by the underlying health conditions which the medications are taken for, known as confounding by indication. Here, we leverage human induced pluripotent stem cells-derived-neurons (hiPSC-Ns) to complement the pharmacoepidemiology studies by directly examining the effects of various anticholinergic classes on dementi

SUBMITTER: Schwarze-Taufiq TA 

PROVIDER: S-EPMC11795422 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature