The role of cognitive reserve and clinical symptoms in the association between genetic liability for educational attainment and functioning in first-episode psychosis: A mediation analysis.

ABSTRACT:

Background

Polygenic risk scores for educational attainment (PRS_EA), cognitive reserve (CR), and clinical symptoms are associated with functioning in first-episode psychosis (FEP). Nevertheless, the mechanisms underlying their complex interaction are yet to be explored. This study assessed the mediating role of CR and clinical symptoms, both negative (NS) and positive (PS), on the interrelationship between PRS_EA and functionality, one year after a FEP.

Methods

A total of 162 FEP patients underwent clinical, functional, and genetic assessments. Using genome-wide association study summary results, PRS_EA were constructed for each individual. Two mediation models were performed. The parallel mediation model explored the relationship of PRS_EA

SUBMITTER: Clougher D 

PROVIDER: S-EPMC11795430 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature