Correlation between carbapenem susceptibility in <i>Pseudomonas aeruginosa</i> and modified antibiotic heterogeneity index: a multicenter observational study using a surveillance platform.

ABSTRACT:

Objective

This study focused on exploring the relationship between antimicrobial use indicators, including the modified antibiotic heterogeneity index (mAHI), and the carbapenem susceptibility in Pseudomonas aeruginosa.

Design

Survey-based observational study conducted across multiple facilities.

Setting

Public community hospital institutions.

Methods

This survey was conducted in 15 community hospitals in Japan. Indicators, such as the defined daily doses (DDDs), days of therapy (DOTs), antibiotic heterogeneity index (AHI), and mAHI, were analyzed for P. aeruginosa carbapenem susceptibility using Spearman's rank correlation. The predictive accuracies of the AHI and mAHI for carbapenem susceptibility were compared using DeLong's test for the 2 corr

SUBMITTER: Sawada K 

PROVIDER: S-EPMC11795433 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature