Carbapenem resistance in the Dominican Republic: clinical characteristics, genotypic profiles, and risk factors.

ABSTRACT:

Objective

To characterize the clinical and microbiological features of carbapenem-resistant Enterobacterales (CRE) compared to carbapenem-susceptible Enterobacterales (CSE) in the Dominican Republic (DR), and to assess risk factors associated with CRE.

Design

Retrospective case-control study.

Setting

Hospital General Plaza de la Salud, a tertiary teaching hospital in Santo Domingo, DR, from January 2015 to June 2024.

Patients

Patients with CRE infections were identified from microbiology records. For each year, a matched group of CSE cases was selected at a 2.5:1 ratio. A total of 101 CRE cases and 280 CSE cases were included.

Methods

Data were collected on demographics, comorbidities, infection sources, hospital stay duration, antibiotic use, and microb

SUBMITTER: Hernandez-Landa RE 

PROVIDER: S-EPMC11795434 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature