Isolated anti-SS-B (La) antibodies: rare occurrence and lack of diagnostic value.

ABSTRACT:

Objective

Anti-SS-B antibodies are often associated with anti-SS-A in Sjögren's disease. Compared to anti-SS-A antibody positivity, the significance of the immunological profile anti-SS-B positive/anti-SS-A negative remains controversial. We aimed to evaluate the prevalence and diagnostic significance of isolated anti-SS-B antibodies.

Methods

We conducted a retrospective study across three hospitals of the Assistance Publique-Hôpitaux de Paris. Patients with anti-SS-B positivity were identified using ELISA, addressable laser beam immunoassay (ALBIA) and immunodot assays. They were retained if anti-SS-B was positive in two techniques and anti-SS-A was absent. Clinical, biological and immunological data were extracted and presented in a descriptive analysis.

Results

A t

SUBMITTER: Cioni P 

PROVIDER: S-EPMC11795515 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature