Premorbid predictors of death at initial presentation of coronary heart disease in the Women's Health Initiative study.

ABSTRACT:

Background

Premorbid health traits that increase the risk of dying at the time of initial presentation of coronary heart disease (CHD) remain poorly characterized.

Methods

We followed 148,230 post-menopausal participants in the Women's Health Initiative for a median of 13.3 years. We ascertained the first occurrence of CHD and performed a joint Cox multivariate regression to identify premorbid predictors for a fatal rather than a non-fatal incident event.

Results

A total of 10,714 incident CHD events including 513 fatal events accrued during follow up. A five-year increase in age, smoking 5 to 34 cigarettes per day, and a standard deviation (SD) increase in the Cornel voltage product, an electrocardiographic measure highly correlated with left ventricular mass index o

SUBMITTER: Chen ML 

PROVIDER: S-EPMC11795550 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature