Lactobacillus gasseri prevents ibrutinib-associated atrial fibrillation through butyrate.

ABSTRACT:

Background

Ibrutinib, a widely used anti-cancer drug, is known to significantly increase the susceptibility to atrial fibrillation (AF). While it is recognized that drugs can reshape the gut microbiota, influencing both therapeutic effectiveness and adverse events, the role of gut microbiota in ibrutinib-induced AF remains largely unexplored.

Method

Utilizing 16S rRNA gene sequencing, faecal microbiota transplantation, metabonomics, electrophysiological examination, and molecular biology methodologies, we sought to validate the hypothesis that gut microbiota dysbiosis promotes ibrutinib-associated AF and to elucidate the underlying mechanisms.

Result

We found that ibrutinib administration pre-disposes rats to AF. Interestingly, ibrutinib-associated microbial transplan

SUBMITTER: Shi L 

PROVIDER: S-EPMC11795659 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature