Crafting Molecular Tools for 15-Lipoxygenase-1 in a Single Step.

ABSTRACT: Small molecule modulators are powerful tools for selectively probing and manipulating proteins in native biological systems. However, the development of versatile modulators that exhibit desired properties is hindered by the lack of a rapid and robust synthetic strategy. Here, we develop a facile and reliable one-step methodology for the generation of multifunctional toolboxes encompassing a wide variety of chemical modulators with different desired features. These modulators bind irreversibly to the protein target via a selective warhead. Key elements are introduced onto the warhead in a single step using multi-component reactions. To illustrate the power of this new technology, we synthesized a library of diverse modulators designed to explore a highly challenging and poorly understood p

SUBMITTER: Louka A 

PROVIDER: S-EPMC11795718 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature