Clinical subtypes in critically ill patients with sepsis: validation and parsimonious classifier model development.

ABSTRACT:

Background

The application of sepsis subtypes to enhance personalized medicine in critically ill patients is hindered by the lack of validation across diverse cohorts and the absence of a simple classification model. We aimed to validate the previously identified SENECA clinical sepsis subtypes in multiple large ICU cohorts, and to develop parsimonious classifier models for δ-type adjudication in clinical practice.

Methods

Data from four cohorts between 2008 and 2023 were used to assign α, β, γ and δ-type in patients fulfilling the Sepsis-3 criteria using clinical variables: (I) The Molecular diAgnosis and Risk stratification of Sepsis (MARS, n = 2449), (II) a contemporary continuation of the MARS study (MARS2, n = 2445) (III) the Dutch National Intensive Care Evaluation reg

SUBMITTER: van Amstel RBE 

PROVIDER: S-EPMC11796029 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature