X-linked ubiquitin-specific peptidase 11 (USP11) increases susceptibility to Cushing's disease in women.

ABSTRACT: The incidence of pituitary adrenocorticotropic hormone (ACTH)-secreting PitNETs, commonly known as ACTH PitNETs, is significantly higher in females; however, the underlying causes for this gender disparity remain unclear. In this study, we analyzed the expression of deubiquitinating enzymes in functioning ACTH PitNETs from both male and female subjects using RNA sequencing and identified USP11 as a potential susceptibility factor contributing to the higher prevalence of these PitNETs in females. Further investigation revealed that USP11 expression is markedly elevated in female functioning ACTH PitNETs, with levels significantly higher than those observed in male PitNETs and normal pituitary tissue. Experimental data indicate that USP11 promotes the transcription of proopiomelanocortin (PO

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11796047 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature