Global birth prevalence of major congenital anomalies: a systematic review and meta-analysis.

ABSTRACT:

Background

There is a lack of systematic review on the global prevalence of major congenital anomalies. We performed a systematic review and meta-analysis of population-based studies on global birth prevalence of eight major congenital anomalies (esophageal atresia, congenital diaphragmatic hernia, duodenal atresia, intestinal atresia, gastroschisis, omphalocele, Hirschsprung's disease and anorectal malformation).

Methods

Population-based studies reporting the birth prevalence of these anomalies were included from 1969 to 2024. Data from eligible studies were pooled in meta-analysis to get global estimates of birth prevalence and prevalence in subgroups of geographic regions, countries with varying income levels and time periods.

Results

One hundred and twenty-three s

SUBMITTER: Xie X 

PROVIDER: S-EPMC11796082 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature