Global biogeography and projection of antimicrobial toxin genes.

ABSTRACT:

Background

Antimicrobial toxin genes (ATGs) encode potent antimicrobial weapons in nature that rival antibiotics, significantly impacting microbial survival and offering potential benefits for human health. However, the drivers of their global diversity and biogeography remain unknown.

Results

Here, we identified 4400 ATG clusters from 149 families by correlating 10,000 samples worldwide with over 200,000 microbial genome data. We demonstrated that global microbial communities universally encode complex and diverse ATGs, with widespread differences across various habitats. Most ATG clusters were rare within habitats but were shared among habitats. Compared with those in animal-associated habitats, ATG clusters in human-associated habitats exhibit greater diversity and a grea

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11796102 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature