PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is a frequent and aggressive type of kidney cancer with limited therapeutic options. Although phosphatase and tensin homolog (PTEN) have been recognized as a potential tumor suppressor in all kinds of cancers, its function in RCC remains to be thoroughly elucidated.

Objective

This article was recruited to examine the PTEN's role in managing the PI3K/AKT pathway and its impact on the RCC cell proliferation and migration.

Methods

This study collected renal cancer and adjacent non-cancerous tissue samples from our hospital. HK-2 and 786-O cells were used, with 786-O cells divided into control, vector, and oe-PTEN groups. PTEN and related protein levels were detected using RT-qPCR and Western blot. Statistical analyses were performed

SUBMITTER: Xu X 

PROVIDER: S-EPMC11796115 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature