One-step diagnosis of infection and lung cancer using metagenomic sequencing.

ABSTRACT:

Background

Traditional detection methods face challenges in meeting the diverse clinical needs for diagnosing both lung cancer and infections within a single test. Onco-mNGS has emerged as a promising solution capable of accurately identifying infectious pathogens and tumors simultaneously. However, critical evidence is still lacking regarding its diagnostic performance in distinguishing between pulmonary infections, tumors, and non-infectious, non-tumor conditions in real clinical settings.

Methods

In this study, data were gathered from 223 participants presenting symptoms of lung infection or tumor who underwent Onco-mNGS testing. Patients were categorized into four groups based on clinical diagnoses: infection, tumor, tumor with infection, and non-infection-non-tumor. Com

SUBMITTER: Li S 

PROVIDER: S-EPMC11796122 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature