Staphylococcus aureus induces mitophagy via the HDAC11/IL10 pathway to sustain intracellular survival.

ABSTRACT:

Background

The immune evasion and prolonged survival of Staphylococcus aureus (S. aureus) within macrophages are key factors contributing to the difficulty in curing osteomyelitis. Although macrophages play a vital role as innate immune cells, the mechanisms by which S. aureus survives within them and suppresses host immune functions remain incompletely understood.

Methods

This study employed confocal microscopy, flow cytometry, ELISA, and siRNA technology to assess the survival capacity of S. aureus within macrophages and the impact of inflammatory cytokines on its persistence. Proteomics was used to investigate the potential mechanisms and differential proteins involved in S. aureus intracellular survival. Additionally, confocal microscopy, flow cytometry, Mdivi-1 interven

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11796158 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature