Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits.

ABSTRACT:

Background

Milk production traits are complex and influenced by many genetic and environmental factors. Although extensive research has been performed for these traits, with many associations unveiled thus far, due to their crucial economic importance, complex genetic architecture, and the fact that causal variants in cattle are still scarce, there is a need for a better understanding of their genetic background. In this study, we aimed to identify new candidate loci associated with milk production traits in German Holstein cattle, the most important dairy breed in Germany and worldwide. For that purpose, 180,217 cattle were imputed to the sequence level and large-scale genome-wide association study (GWAS) followed by fine-mapping and evolutionary and functional annotation were car

SUBMITTER: Krizanac AM 

PROVIDER: S-EPMC11796172 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature