Case report of glomerular histiocytosis associated with non-crystalline IgG-kappa paraproteinemia.

ABSTRACT:

Background

Monoclonal gammopathy of renal significance (MGRS) represents a range of disease processes arising from monoclonal proteins depositing in the kidney. These deposits vary and can be broadly grouped as containing a substructure or being non-organised. Their clinical phenotype can include proteinuria, haematuria, kidney injury and tubulopathies resulting in electrolyte changes.

Case presentation

Crystal storing histiocytosis (CSH) is a rare form of MGRS that typically deposits in the interstitium but rarely in the glomerulus to cause progressive kidney disease. We report a case of a male with known monoclonal protein and progressive proteinuria, whose biopsy showed glomerular histiocytosis with non-crystallizing IgG kappa inclusions.

Conclusion

This case revie

SUBMITTER: Kishore A 

PROVIDER: S-EPMC11796192 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature