Age-related changes in DNA methylation in a sample of elderly Brazilians.

ABSTRACT:

Background

Age-related changes in DNA methylation (DNAm) play a critical role in regulating gene expression. However, most epigenome-wide association studies have predominantly focused on individuals of European descent. This study aims to characterize longitudinal changes in DNAm patterns in a cohort of elderly Brazilian participants.

Methods

DNAm profiles were collected approximately nine years apart from 23 elderly Brazilian individuals using the Illumina Infinium MethyationEPIC BeadChip. Using mixed-effects models, we examined changes in DNAm patterns using both quantitative age and binary timepoint (e.g., baseline vs. follow-up) as predictors of interest to identify differentially methylated positions (DMPs). Significant DMPs were compared with a list of previously iden

SUBMITTER: Welsh H 

PROVIDER: S-EPMC11796210 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature