Wnt signaling as a translational target in rheumatoid and psoriatic arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) are chronic inflammatory diseases mainly affecting joints. RA primarily targets the synovial joints and is characterized by cartilage and bone erosion, whereas PsA is associated with skin and nail psoriasis and is characterized by erosive bone damage with an exuberant bone formation and soft tissue involvement. Recent evidence described the involvement of the Wnt pathway in the pathogenesis of these diseases. Thus, we aimed to analyze some components of Wnt signaling, i.e. DKK1, Wnt 5a and β-catenin, and their association with disease activity indices, investigating possible differences between the two diseases.

Methods

Sera from 18 RA patients naïve for biological therapy, 18 PsA patients and 20 matched heal

SUBMITTER: Riitano G 

PROVIDER: S-EPMC11796213 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature